Student projects – University of Copenhagen

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Department of Neuroscience and Pharmacology > Education > Student projects

Student projects

Brain Research and Integrative Neuroscience Laboratory

Group Project Contact information
Linda Bergersen Research Group We welcome Master and PhD students for supervision on projects within our research topics, with the view to recruiting future collaborators. Linda Bergersen

 

Molecular Neuropharmacology and Genetics Laboratory

Group Project Contact information
Molecular Neuropharmacology Group

Cellular regulation and molecular genetics of neurotransmitter transporters and receptors

Are you interested in molecular and cellular neurobiology? Do you want to understand how neurons control activity and availability of neurotransmitter receptors and transporters in the synapse? Are you interested in understanding how mutations in these proteins contribute to CNS-diseases such as depression, ADHD, Parkinson’s disease, schizophrenia and addiction? Do you want to know how you become addicted to drugs such as cocaine or amphetamine?

Ulrik Gether
 

Molecular pharmacology and structure of neurotransmitter transporters

Would you like to know how membrane proteins like neurotransmitter transporters work at the molecular level? Are you interested in using crystallography and advanced fluorescence techniques to study their transport function? Do you want to characterize how drugs act on neurotransmitter transporters? Are you interested in finding new ways to discover drugs for treatment of e.g. cocaine addiction and depression?

Claus Juul Loland 

 

Ulrik Gether

 

Neuronal scaffolding proteins and protein trafficking

Are you interested in how neuronal scaffolding proteins regulate synaptic signaling processes? Would you like to know if scaffolding proteins could be a new target for treatment of CNS-diseases such as stroke and addiction? Would you like to understand the role of membrane-shaping protein domains (e.g. BAR domains) in neuronal scaffolding? Do you want to know how BAR domain proteins control protein trafficking not only in neurons but also in other cells such as endocrine cells?

Kenneth L. Madsen

 

Ulrik Gether

 

Neural Control of Movement

Group Project Contact information
Cerebral palsy, Spasticity & Neurorehabilitation If you are looking for a bachelor- or master thesis project in the field of Cerebral palsy and find our research interesting, please feel free to contact us. We strive to incorporate your interests and ideas within our research field. Jens Bo Nielsen
Congnitive Motor Neuroscience If you are looking for a master thesis project in the field of cognitive motor neuroscience and find our research interesting, please feel free to contact us. We strive to incorporate your interests and ideas within our research field. Mark Christensen
Mouse Spinal Motor Control Group We have yearly openings for graduate students to do projects in the lab. Due to the nature of our experiments a considerable amount of supervision is required meaning that we have to restrict the numbers possible. We are currently full until Jan 2014. If you are interested in performing a project in the laboratory next year however, please send your CV to claire@sund.ku.dk Claire Meehan
Sensori-motor systems Group We are currently looking for students interested in doing their Bachelor, Master, or PhD project in our group. We will actively support the application of suitable students for scholarships from various sources. The projects might include both electrophysiological, optical and molecular biology techniques Jens C. Rekling

 

Laboratory of Neural Plasticity

Group Project Contact information
Neuro-Oncology Group

Master students are very welcome to join us in the following projects.

  • Development of 3D astrocyte culture model to identify new astrocyte-derived factors that stimulate tumor progression.
  • Study the mechanism of S100A4-positive micro-particle formation.
  • Implementation of S100A4 antagonistic peptides to block brain metastases formation.
Noona Ambartsumian

Neuronal Signalling Laboratory

Group Project Contact information
Jean-Francois Perrier

Role of PKMζ in the subiculum

Joint project between the labs of Jean-Francois Perrier (DNP) and Shohreh Issazadeh-Navikas (BRIC)
 
Rationale of the project
Long-term potentiation (LTP) is a form of plasticity that occurs in the limbic system. It is now well admitted that LTP is the cellular basis for learning and memory and scientists who contributed to its discovery were awarded the Brain Prize few weeks ago. The molecular mechanisms underlying the establishment of LTP are now well described. However, understanding how memory can be maintained over long periods (days to years) is a remaining challenge. It was recently suggested that Protein kinase Mζ (PKMζ), an atypical protein kinase C (PKC) isoform, plays a key role in the maintenance LTP. In addition, it was found in Alzheimer disease models that PKMζ accumulates in neurofibrillary tangles in brain areas involved in memory formation. Neurofibrillary tangles accumulate particularly in the hippocampal formation area called subiculum. Mice lacking IFN-β develop cognitive dysfunction and pathology in subiculum (Ejlerskov et. al. 2015 Cell). For that reason, our laboratories have decided to investigate the role PKMζ in the subiculum of normal versus mice lacking IFN-β and its receptor.
 
Experiments
We are looking for one or two highly motivated master students to perform experiments in a slice preparation from the mouse brain as well as primary hippocampal neuronal cultures. We wish also to investigate if PKMζ is influences as a result of the genetic defects using Western blot and PCR techniques.
By performing patch-clamp recording of subicular neurons and calcium imaging with multi-photon microscopy, you will determine if and how PKMζ participate to memory formation in the subiculum in a healthy mouse and in the neurodegenerative models with dementia.

Jean-Francois Perrier

 

Shohreh Issazadeh-Navikas