Linda Bergersen Research Group – University of Copenhagen

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Research

Linda H. Bergersen’s group investigates the ultrastructural localization of proteins involved in brain energy production and neurotransmission, and recently established lactate ‘volume transmission’ by discovering the lactate receptor GPR81 in the brain. In collaboration with the Center for Healthy Aging (CEHA), she also examines mechanisms of DNA repair and mitochondrial function/dysfunction. Disease relevance includes ADHD, epilepsy, schizophrenia, glaucoma, and dementia.

Collaborations

Håvard Attramadal (NO)
David Attwell (UK)
Magnar Bjørås (NO)
David A. Clayton (USA)
Tore Eid (USA)
Fred H. Gage (USA)
Albert Gjedde (DK & CA)
Øyvind Hvalby (NO)
Tim Karl (AU)
Arne Klungland (NO)
Miriam Kolko (DK)
Stefan Offermanns (DE)
Erik Pettersen (NO)
Serge Przedborski (USA)
Lene Juul Rasmussen (DK)
Andrea Volterra (CH)

Recent results

Synapses sense lactate
Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism.
Lauritzen KH, Morland C, Puchades M, Holm-Hansen S, Hagelin EM, Lauritzen F, Attramadal H, Storm-Mathisen J, Gjedde A, Bergersen LH. Cereb Cortex Epub 21 May 2013 (doi:10.1093/cercor/bht136)

The paper shows that the lactate receptor GPR81 downregulates cAMP production in the brain in response to increased lactate levels, such as occur in physical exercise. The receptor is concentrated at the postsynaptic membranes of glutamatergic synapses on cortical pyramidal cells, including in the hippocampus. The lactate receptor, was originally identified in adipocytes as part of an autocrine / paracrine loop whereby increased production of lactate inhibits lipolysis through downregulating cAMP. Lauritzen at al. suggest that, in the brain, the lactate receptor allows lactate released by activated neurons to act as a “volume transmitter” that tells brain cells to adjust their condition by curbing cAMP production. The new findings point to the lactate receptor as a potential therapeutic target in brain.

Openings, student projects

We welcome Master and PhD students for supervision on projects within our research topics, with the view to recruiting future collaborators. Please contact LHB for discussions.