Miriam Kolko Eye research Group – University of Copenhagen

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Research

The group aim to understand the cascade reactions leading to retinal ganglion cell (RGC) death. In particular we focus on models to study the interaction between RGC and Müller cells. Hence, we aim to elucidate how various forms of stress affect the ability of Müller cells to protect RGC. A special focus on energy metabolism and mitochondrial activity has recently been raised.

Glaucoma research

Glaucoma is one of the leading causes of blindness worldwide. Overall, glaucoma is defined by a progressive optic neuropathy characterized by the loss of retinal ganglion cells (RGC). The Eye research group aims to develop a strategy for glaucoma treatment directed against the glia cells supporting RGC, the Müller cells. Müller cells supply the RGC with essential nutrients and signaling components and remove damaging neurotransmitters released from the RGC. The Eye research group has set up a model of glaucoma focusing on the Müller cells that will be used to investigate the functional interaction between RGC and Müller cells, and elucidate how glaucomatous stress effect the ability of Müller cells to support RGC.