Molecular Neuropharmacology and Genetics Laboratory – University of Copenhagen

Our Laboratory and Research

The overall purpose of our research is to achieve insight into molecular, cellular and genetic processes responsible for synaptic signal transmission and how these processes can be modulated by drugs. We have main focus on the presynaptic transporters for the biogenic amine transmitters, dopamine, norepinephrine and serotonin. In addition, we have a major interest in ‘scaffolding' proteins that via specific protein-protein interactions and protein-lipid interactions organize neurotransmitter transporters and receptors into desired cellular microdomains and multiprotein signaling complexes.

Alliances & Collaboration

We collaborate with several research laboratories around the world. See a list of collaboration partners here.

Join us

We can give you the opportunity to use state-of-the art techniques to address fundamental questions in neurobiology and neuropharmacology. We offer a dynamic research environment where competent supervision, scientific excellence and knowledge sharing have highest priority. Possible projects range from structural and dynamic studies of neurotransmitter receptors and transporters as well as their associated scaffolding proteins to integrated studies in genetic mouse models with relevance for CNS-related diseases such as depression, ADHD, Parkinson’s disease, schizophrenia and addiction. We invite highly motivated, dedicated and skilled students, who wish to join the laboratory, to contact one of the Laboratory's senior members:

Ulrik Gether
Ole Kjærulff
Claus Juul Løland
Kenneth Lindegaard Madsen
Per Krenger Plenge 

Søren Gøgsig Faarup Rasmussen

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Groups

Molecular Neuropharmacology and Genetics Laboratory counts ~35 people and is separated into five Groups with focus on 1) cellular biology and genetics of neurotransmitter transporters/receptors (headed by Ulrik Gether), 2) molecular pharmacology and structure of neurotransmitter transporters (headed by Associate Professor Claus J. Løland), 3) cellular ‘scaffolding’ processes in the CNS (headed by Associate Professor Kenneth L. Madsen), structural biology of G protein coupled receptors and transport proteins (headed by Assistant Professor Søren G. F. Rasmussen and 5) neuronal signaling in Drosophila melanogaster (the fruit fly) (headed by Associate Professor Ole Kjærulff).

 

 

Research Partnerships

The laboratory is supported by major grants from the Lundbeck Foundation, the Danish Research Councils, National Institute of Drug Abuse U.S.A., University of Copenhagen, EU and the Novo Nordisk Foundation. The laboratory is part of Lundbeck Foundation Center for Biomembranes in Nanomedicine (Directors Ulrik Gether and Dimitrios Stamou), Center for Synthetic Biology and the UCPH 2016 programs of excellence Attention to dopamine.