Publications – University of Copenhagen

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Neuropharmacology > Publications

Molecular Neuropharmacology and Genetics Laboratory

Publications

2016

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter
Billesbølle, Christian B; Mortensen, Jonas S; Sohail, Azmat; Schmidt, Solveig G; Shi, Lei; Sitte, Harald H; Gether, Ulrik; Loland, Claus J.
Nature Communications, Vol. 7, 12755, 28.09.2016

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu(290)
Khelashvili, George; Schmidt, Solveig Gaarde; Shi, Lei; Javitch, Jonathan A.; Gether, Ulrik; Loland, Claus J.; Weinstein, Harel.
Journal of Biological Chemistry, Vol. 291, Nr. 38, 16.09.2016, s. 19786-19799.

The Environment Shapes the Inner Vestibule of LeuT
Azmat Sohail ; Kumaresan Jayaraman ; Santhoshkannan Venkatesan ; Kamil Gotfryd ; Markus Daerr ; Ulrik Gether ; Claus J Loland ; Klaus T Wanner ; Michael Freissmuth ; Harald H Sitte ; Walter Sandtner ; Thomas Stockner
PLoS computational biology, Vol. 12, No. 11, nov. 2016, pp 1-24

Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice
Annika Højrup Runegaard Thomsen ; Kathrine L Jensen ; Ciarán M Fitzpatrick ; Ditte Dencker ; Pia Weikop ; Ulrik Gether ; Karl Mattias Rickhag
European Journal of Neuroscience, online 22 August 2016, on print; Volume 45, Issue 1, January 2017, pp 121–128.

A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function
Anne Elina Vuorenpää ; Ina Ammendrup-Johnsen ; Trine N. Jorgensen ; Ulrik Gether
Neurochemistry International, Vol. 98, September 2016, pp. 103-114

Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial.
Knorr, Ulla; Koefoed, Pernille; Gluud, Christian; Wetterslev, Jørn; Winkel, Per; Gether, Ulrik; Vinberg, Maj; Kessing, Lars V.
Nordic Journal of psychiatry, Vol. 70, No. 4, 11.01.2016, pp. 297-302.

No effect of escitalopram versus placebo on brain-derived neurotrophic facor in healthy individuals: a randomised trial.
Knorr, Ulla; Koefoed, Pernille; Soendergaard, Mia H G; Vinberg, Maj; Gether, Ulrik; Gluud Christian; Wetterslev, Jørn; Winkel, Per; Kessing, Lars V.
Acta Neuropsychiatria (Online), Vol. 28, No. 2, 04.2016, pp. 101-109.

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter.
Larsen, M Andreas B, Plenge, Per; Andersen, Jacob, Eildal, Jonas N N; Kristensen, Anders S; Bøgesø, Klaus, P; Gether, Ulrik; Strømgaard, Kristian; Bang-Andersen, Benny; Loland, Claus J.
British Journal of Pharmacology, Vol. 173, No. 5, 03.2016, pp. 925-936.

2015


Optogenetik bringer neurale maknismer frem i lyset og kan blive en ny terapiform.
Axelsen, Tobias Melton; Navntoft, Charlotte Amalie Emdal; Christiansen, Søren Hofman; Dryer, Jakob Kisbye; Sørensen, Jakob Balslev; Gether, Ulrik; Woldbye, David Poul Drucker.
Ugeskrift for laeger, Vol. 177, No. 34, V06150501; 17.08.2015, pp, 2-5.

Substrate-induced Unlocking of the inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter.
Billesboelle, Christian B; Kruger, Mie B; Shi, Lei; Quick, Matthias; Li, Zheng; Stolzenberg, Sebastian; Kniazeff, Julie; Gotfryd, Kamil; Mortensen, Jonas S; Javitch, Jonathan A; Weinstein, Harel; Loland, Claus J; Gether, Ulrik.
The Journal of Biological Chemistry, Vol. 290, No. 44, 30.10.2015, pp. 26725-26738.

Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDATR51W) in dopamine neurotransmission and behaviors. Cartier, Etienne; Hamilton, Peter J; Belovich, Andrea N; Shekar, Aparna; Campbell, Nicholas G; Saunders, Christine; Andreassen, Thorvald F; Gether, Ulrik; Veenstra-Vanderweele, Jeremy; Sutcliffe, James S; Ulery-Reynolds, Paula G; Erreger, Kevin; Matthies, Heinrich J G; Galli, Aurelio.
EBioMedicine, Vol. 2, No. 2, 02.2015, pp. 135-146.

A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity.
Christiansen, Mia Apuschkin; Stilling, Sara; Rahbek-Clemmensen, Troels; Sørensen Gunnar; Fortin, Guillaume; Herborg Hansen, Freja; Eriksen, Jacob; Trudeau, Louis-Eric; Egerod, Kristoffer; Gether, Ulirk; Rickhag, Karl Mattias.
European Journal of Neuroscience, Vol. 42, Mo. 7, 2015, pp. 2438-2454.

Structure of dimeric and tetrameric complexes of the BAR domain PICK1 determined by small-angle X-Ray scattering.
Karlsen, Morten L; Thorsen, Thor S; Johner, Niklaus; Ammendrup-Johnsen, Ina; Erlendsson, Simon; Tian, Xinsheng; Simonsen, Jens B; Hoiberg-Nielsen, Rasmus; Christensen, Nikolaj M; Khelashvili, George; Streicher, Werner; Teilum, Kaare; Vestergaard, Bente; Weinstein, Harel; Gether, Ulrik; Arleth, Lise; Madsen, Kenneth L.
Structure, Vol. 23, No. 7, 07.07.2015, pp. 1258-1270.

Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation. Rajamanickam, Jeyaganesh; Annamalai, Balasubramaniam; Rahbek-Clemmensen, Troels; Sundaramurthy, Santhanalakshmi; Gether, Ulrik; Jayanthi, Lankupalle D; Ramamoorthy, Sammanda.
Biochemical Journal, Vol. 468, No. 1, BJ20140826, 15.05.2015, pp. 177-90.

Functional regulation of amphetamine-induced efflux by CaMKII.
Sitte, Harald H; Steinkellner, Thomas; Montgomery, Therese R; hofmaier, Tina; Kudlacek, Oliver; Yang, Jae-Won; Jung, Gangsoo; Lubec, Gert; Gether, Ulrik; Freissmuth, Michael; Pollak, Daniella D.
Amino Acid, Vol. 48, No. 8, 08.2015, pp. 1659-1659.

Amphetamine Action at the Cocaine- and Antidepressant-Sensitive Serotonin Transporter Is Modulated by αCaMKII. Steinkellner, Thomas; Montgomery, Therese R; Hofmaier, Tina; Kudlacek, Oliver; Yang, Jae-Won; Rickhag, Karl Mattias; Jung, Gangsoo; Lubec, Gert; Gether, Ulrik; Freissmuth, Michael; Sitte, Harald H.
The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, No. 21, 2015, pp. 8258-71.

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. Stolzenberg, Sebastian; Quick, Matthias; Zhao, Chunfeng; Gotfryd, Kamil; Khelashvili, George; Gether, Ulrik; Loland, Claus J; Javitch, Jonathan A; Noskov, Sergei; Weinstein, Harel; Shi, Lei.
The Journal of biological chemistry, Vol. 290, No. 22, 2015, pp. 13992-4003.

2014


The second sodium site in the dopamine transporter controls cation permeability and is regulated by chloride. Borre, Lars; Andreassen, Thorvald F; Shi, Lei; Weinstein, Harel; Gether, Ulrik.
The Journal of biological chemistry, Vol. 289, 25.07.2014, pp. 25764-25773.

The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells. da Silva Pinheiro, Paulo César; Jansen, Anna M; de Wit, Heidi; Tawfik, Bassam; Madsen, Kenneth L; Verhage, Matthijs; Gether, Ulrik; Sørensen, Jakob Balslev.
The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, No. 32, 06.08.2014, pp. 10688-700.

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/Discs-Large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands. Erlendsson, Simon; Rathje, Mette; Heiðarsson, Pétur Orri; Poulsen, Flemming Martin; Madsen, Kenneth Lindegaard; Teilum, Kaare; Gether, Ulrik.
Journal of Biological Chemistry, Vol. 289, No. 36, 2014, pp. 25327-25340.

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. Hansen, Freja H; Skjørringe, Tina; Yasmeen, Saiqa; Arends, Natascha V; Sahai, Michelle A; Erreger, Kevin; Andreassen, Thorvald F; Holy, Marion; Hamilton, Peter J; Neergheen, Viruna; Karlsborg, Merete; Newman, Amy H; Pope, Simon; Heales, Simon J R; Friberg, Lars; Law, Ian; Pinborg, Lars H; Sitte, Harald H; Loland, Claus; Shi, Lei; Weinstein, Harel; Galli, Aurelio; Hjermind, Lena E; Møller, Lisbeth B; Gether, Ulrik.
The Journal of clinical investigation, Vol. 124, No. 7, 01.07.2014, pp. 3107-20.

Serotonin-induced down-regulation of cell surface serotonin transporter. Jørgensen, Trine Nygaard; Christensen, Peter Møller; Gether, Ulrik.
Neurochemistry international, Vol. 73, 07.2014, pp. 107-12.

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. Kumar, Vivek; Rahbek-Clemmensen, Troels; Billesbølle, Christian B; Jorgensen, Trine Nygaard; Gether, Ulrik; Newman, Amy Hauck.
ACS Medicinal Chemistry Letters, Vol. 5, No. 6, 12.06.2014, pp. 696-9.

The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation. Rahbek-Clemmensen, Troels; Bay, Tina; Eriksen, Jacob; Gether, Ulrik; Jørgensen, Trine Nygaard.
The Journal of biological chemistry, Vol. 289, 27.06.2014, pp. 23004-23019.

Reply to Wilkinson et al. : Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling. Rathje, Mette; Fang, Huaqiang; Bachman, Julia L; Gether, Ulrik; Huganir, Richard L; Madsen, Kenneth L.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 3, 21.01.2014, pp. E305.

In vivo amphetamine action is contingent on αCaMKII. Steinkellner, Thomas; Mus, Liudmilla; Eisenrauch, Birgit; Constantinescu, Andreea; Leo, Damiana; Konrad, Lisa; Rickhag, Karl Mattias; Sørensen, Gunnar; Efimova, Evgenia V; Kong, Eryan; Willeit, Matthäs; Sotnikova, Tatyana D; Kudlacek, Oliver; Gether, Ulrik; Freissmuth, Michael; Pollak, Daniela D; Gainetdinov, Raul R; Sitte, Harald H.
Neuopsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 39, No. 11, 10.2014, pp. 2681-93.

2013


Correction to "tandem facial amphiphiles for membrane protein stabilization. Chae, Pil Seok; Gotfryd, Kamil; Pacyna, Jennifer; Miercke, Larry J W; Rasmussen, Søren G F; Robbins, Rebecca A; Rana, Rohini R; Loland, Claus J; Kobilka, Brian; Stroud, Robert; Byrne, Bernadette; Gether, Ulrik; Gellman, Samuel H.
Journal of the American Chemical Society, Vol. 135, No. 34, 28.08.2013, pp. 12922.

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. Chae, Pil Seok; Rana, Rohini R; Gotfryd, Kamil; Rasmussen, Søren G F; Kruse, Andrew C; Cho, Kyung Ho; Capaldi, Stefano; Carlsson, Emil; Kobilka, Brian; Loland, Claus J; Gether, Ulrik; Banerjee, Surajit; Byrne, Bernadette; Lee, John K; Gellman, Samuel H.
Chemical communications (Cambridge, England), Vol. 49, No. 23, 21.03.2013, pp. 2287-9.

Novel Tripod Amphiphiles for Membrane Protein Analysis. Chae, Pil Seok; Kruse, Andrew C; Gotfryd, Kamil; Rana, Rohini R; Cho, Kyung Ho; Rasmussen, Søren G F; Bae, Hyoung Eun; Chandra, Richa; Gether, Ulrik; Guan, Lan; Kobilka, Brian K; Loland, Claus J; Byrne, Bernadette; Gellman, Samuel H.
Chemistry: A European Journal, Vol. 19, No. 46, 02.10.2013.

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Hamilton, P J; Campbell, N G; Sharma, S; Erreger, K; Hansen, Freja Herborg; Saunders, C; Belovich, A N; NIH ARRA Autism Sequencing Consortium; Sahai, M A; Cook, E H; Gether, U; McHaourab, H S; Matthies, H J G; Sutcliffe, J S; Galli, A.
Molecular Psychiatry, Vol. 18, No. 12, 12.2013, pp. 1315-23.

Drosophila melanogaster : a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene. Hamilton, P J; Campbell, N G; Sharma, S; Erreger, K; Hansen, F H; Saunders, C; Belovich, A N; Sahai, M A; Cook, E H; Gether, U; McHaourab, H S; Matthies, H J G; Sutcliffe, J S; Galli, A.
Molecular Psychiatry, Vol. 18, No. 12, 12.2013, pp. 1235.

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. Holst, Birgitte; Madsen, Kenneth L; Jansen, Anna M; Jin, Chunyu; Rickhag, Karl Mattias; Lund, Viktor K; Jensen, Morten; Bhatia, Vikram; Sørensen, Gunnar; Madsen, Andreas N; Xue, Zhichao; Møller, Siri K; Woldbye, David; Qvortrup, Klaus; Huganir, Richard; Stamou, Dimitrios; Kjærulff, Ole; Gether, Ulrik.
P L o S Biology (Online), Vol. 11, No. 4, e1001542, 04.2013, pp. 1-25.

Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort. Larsen, Margit Hørup; Albrechtsen, Anders; Thørner, Lise Wegner; Werge, Thomas; Hansen, Thomas; Gether, Ulrik; Haastrup, Eva; Ullum, Henrik.
PloS one, Vol. 8, No. 6, e66262, 2013.

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons. Rathje, Mette; Fang, Huaqiang; Bachman, Julia L; Anggono, Victor; Gether, Ulrik; Huganir, Richard L; Madsen, Kenneth L.

I: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 35, 27.08.2013, pp. 14426-31.


A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Rickhag, Karl Mattias; Hansen, Freja Herborg; Sørensen, Gunnar; Strandfelt, Kristine Nørgaard; Andresen, Bjørn; Gotfryd, Kamil; Madsen, Kenneth L; Vestergaard-Klewe, Ib; Ammendrup-Johnsen, Ina; Eriksen, Jacob; Newman, Amy H; Füchtbauer, Ernst-Martin; Gomeza, Jesus; Woldbye, David P D; Wörtwein, Gitta; Gether, Ulrik.

Nature Communications, Vol. 4, 1580, 2013, pp. 1-13.
Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine releaseRickhag, Karl Mattias; Owens, WA; Winkler, Marie-Therese; Strandfelt, Kristine Nørgaard; Rathje, Mette; Sørensen, Gunnar; Andresen, Bjørn; Madsen, Kenneth Lindegaard; Nygaard Jørgensen, Trine; Wörtwein, Gitta; Woldbye, David Paul Drucker; Sitte, Harald H; Daws, Lynette C.; Gether, Ulrik.
Journal of Biological Chemistry, Vol. 288, 2013, pp. 27534-44.
 
A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT. Simmons, Katie J; Gotfryd, Kamil; Billesbølle, Christian B; Loland, Claus J; Gether, Ulrik; Fishwick, Colin W G; Johnson, A Peter.
Molecular Membrane Biology, Vol. 30, No. 2, 03.2013, pp. 184-94.
 

2012

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding. Ammendrup-Johnsen, Ina; Thorsen, Thor Seneca; Gether, Ulrik; Madsen, Kenneth Lindegaard.
Biochemistry, Vol. 51, No. 2, 17.01.2012, pp. 586-96.

The solute carrier 6 family of transporters. Bröer, Stefan; Gether, Ulrik.
British journal of pharmacology, Vol. 167, No. 2, 22.08.2012, pp. 256-78.

A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins. Chae, Pil Seok; Rasmussen, Søren G F; Rana, Rohini R; Gotfryd, Kamil; Kruse, Andrew C; Manglik, Aashish; Cho, Kyung Ho; Nurva, Shailika; Gether, Ulrik; Guan, Lan; Loland, Claus J; Byrne, Bernadette; Kobilka, Brian K; Gellman, Samuel H.
Chemistry: A European Journal, Vol. 18, No. 31, 27.07.2012, pp. 9485-90.

Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression : a randomized trial. Knorr, Ulla; Vinberg, Maj; Mortensen, Erik Lykke; Winkel, Per; Gluud, Christian; Wetterslev, Jørn; Gether, Ulrik; Kessing, Lars Vedel.
P L o S One, Vol. 7, No. 2, 29.02.2012, pp. e31980.

The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial. Knorr, Ulla; Vinberg, Maj; Gether, Ulrik; Winkel, Per; Gluud, Christian; Wetterslev, Jørn; Kessing, Lars Vedel.
Psychiatry Research Review, Vol. 200, No. 2-3, 30.12.2012, pp. 354-60.

Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression. Koefoed, Pernille; Woldbye, David Paul Drucker; Hansen, Thomas v.O; Eplov, Lene F; Christiansen, Søren Hofman Oliveira; Mors, Ole; Kessing, Lars Vedel; Werge, Thomas; Kaipio, Katja; Pesonen, Ullamani; Fahmy, Thomas; Mellerup, Erling Thyge; Jakobsen, Klaus D; Hansen, Elsebeth S; Knudsen, Gitte Moos; Bukh, Jens D; Bock, Camilla; Lindberg, Camilla; Kristensen, Ann S; Dam, Henrik; Nordentoft, Merete; Als, Thomas D; Wang, August G.; Gether, Ulrik; Rehfeld, Jens Frederik; Bolwig, Tom Gert.

Acta Neuropsychiatrica (Online), Vol. 24, No. 2, 23.03.2012, pp. 81-90.
 
 
Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway. Madsen, Kenneth Lindegaard; Thorsen, Thor Seneca; Rahbek-Clemmensen, Troels; Eriksen, Jacob Møller; Gether, Ulrik.
The Journal of biological chemistry, Vol. 287, No. 15, 06.04.2012, pp. 12293-308.
 
Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. Plenge, Per; Shi, Lei; Beuming, Thijs; Te, Jerez; Newman, Amy Hauck; Weinstein, Harel; Gether, Ulrik; Loland, Claus J.
The Journal of biological chemistry, Vol. 287, No. 47, 16.11.2012, pp. 39316-26.
 

2011

Differences between early and late onset adult depression. Drachmann Bukh, Jens; Bock, Camilla; Vinberg, Maj; Gether, Ulrik; Kessing, Lars Vedel.
Clinical Practice and Epidemiology in Mental Health, Vol. 7, 2011, pp. 140-147.

The binding sites for benztropines and dopamine in the dopamine transporter overlap. Jensen, Heidi Bisgaard; Larsen, M Andreas B; Mazier, Sonia; Beuming, Thijs; Weinstein, Harel; Shi, Lei; Loland, Claus J; Gether, Ulrik.
Neuropharmacology, Vol. 60, No. 1, 01.01.2011, pp. 182-90.

A randomized trial of the effect of escitalopram versus placebo on cognitive function in healthy first-degree relatives of patients with depression. Knorr, Ulla; Vinberg, Maj; Gade, Anders; Winkel, Per; Christian, Gluud; Wetterslev, Jørn; Gether, Ulrik; Kessing, Lars Vedel.
Therapeutic Advances in Psychopharmacology, Vol. 1, No. 5, 10.2011, pp. 133-144.

Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial. Knorr, Ulla; Vinberg, Maj; Hansen, Allan; Klose, Marianne; Feldt-Rasmussen, Ulla; Hilsted, Linda; Hasselstrøm, Jørgen; Gether, Ulrik; Winkel, Per; Gluud, Christian; Wetterslev, Jørn; Kessing, Lars Vedel
PLoS One, Vol. 6, No. 6, 2011, pp. e21224.
SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation. Kristensen, Anders S; Andersen, Jacob; Jørgensen, Trine N; Sørensen, Lena; Eriksen, Jacob; Loland, Claus J; Strømgaard, Kristian; Gether, Ulrik.
Pharmacological Reviews, Vol. 63, No. 3, 01.09.2011, pp. 585-640.

Copy number variations in affective disorders and meta-analysis. Olsen, Line; Hansen, Thomas; Djurovic, Srdjan; Haastrup, Eva; Albrecthsen, Anders; Hoeffding, Louise K E; Secher, Anna; Gustafsson, Omar; Jakobsen, Klaus D; Nielsen, Finn C; Ullum, Henrik; Morken, Gunnar; Agartz, Ingrid; Melle, Ingrid; Gether, Ulrik; Andreassen, Ole A; Werge, Thomas.

Psychiatric Genetics, Vol. 21, No. 6, 2011, pp. 319-322.

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain. Thorsen, Thor S; Madsen, Kenneth L; Dyhring, Tino; Bach, Anders; Peters, Dan; Strømgaard, Kristian; Rønn, Lars Christian B; Gether, Ulrik.
Combinatorial Chemistry & High Throughput Screening, Vol. 14, No. 7, 01.08.2011, pp. 590-600.

Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. Vaz, Sandra H; Jørgensen, Trine Nygaard; Cristóvão-Ferreira, Sofia; Duflot, Sylvie; Ribeiro, Joaquim A; Gether, Ulrik; Sebastião, Ana M.
Journal of Biological Chemistry, Vol. 286, No. 47, 2011, pp. 40464-76.

2010 Publications

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. Bach, Anders; Stuhr-Hansen, Nicolai; Thorsen, Thor S; Bork, Nicolai; Moreira, Irina S; Frydenvang, Karla; Padrah, Shahrokh; Christensen, S Brøgger; Madsen, Kenneth L; Weinstein, Harel; Gether, Ulrik; Strømgaard, Kristian.
Organic & Biomolecular Chemistry, Vol. 8, No. 19, 2010, pp. 4281-4288.

Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression. Bukh, Jens Drachmann; Bock, Camilla; Vinberg, Maj; Gether, Ulrik; Kessing, Lars Vedel; Bukh, Jens Otto Drachmann.
Journal of Affective Disorders, Vol. 127, No. 1-3, 01.12.2010, pp. 199-202.

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Chae, Pil Seok; Rasmussen, Søren G F; Rana, Rohini R; Gotfryd, Kamil; Chandra, Richa; Goren, Michael A; Kruse, Andrew C; Nurva, Shailika; Loland, Claus J; Pierre, Yves; Drew, David; Popot, Jean-Luc; Picot, Daniel; Fox, Brian G; Guan, Lan; Gether, Ulrik; Byrne, Bernadette; Kobilka, Brian; Gellman, Samuel H.
Nature Methods, Vol. 7, 2010, pp. 1003-8.

Tandem Facial Amphiphiles for Membrane Protein Stabilization. Chae, Pil Seok; Gotfryd, Kamil; Pacyna, Jennifer; Miercke, Larry J W; Rasmussen, Søren G F; Robbins, Rebecca A; Rana, Rohini R; Loland, Claus J; Kobilka, Brian; Stroud, Robert; Byrne, Bernadette; Gether, Ulrik; Gellman, Samuel H.
Journal of the American Chemical Society, Vol. 132, No. 47, 01.12.2010, pp. 16750-2.

Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. Eriksen, Jacob; Bjørn-Yoshimoto, Walden Emil; Jørgensen, Trine Nygaard; Newman, Amy Hauck; Gether, Ulrik.
Journal of Biological Chemistry, Vol. 285, No. 35, 2010, pp. 27289-301.

Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges. Eriksen, Jacob; Jørgensen, Trine Nygaard; Gether, Ulrik.
Journal of Neurochemistry, Vol. 113, No. 1, 2010, pp. 27-41.

BAR domains, amphipathic helices and membrane-anchored proteins use the same mechanism to sense membrane curvature. Madsen, Kenneth Lindegaard; Bhatia, V K; Gether, U; Stamou, D.

FEBS Letters, Vol. 584, No. 9, 2010, pp. 1848-55.
  
David versus Goliath. Mollenhauer, Jan; Stamou, Dimitrios; Flyvbjerg, Allan; Wengel, Jesper; Gether, Ulrik; Kjems, Jørgen; Bjørnholm, Thomas; Besenbacher, Flemming.

Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 6, No. 4, 2010, pp. 504-9.

Gender Differences among Patients with a Single Depressive Episode. Bukh, Jens D; Bock, Camilla; Vinberg, Maj; Gether, Ulrik; Kessing, Lars Vedel; Bukh, Jens Otto Drachman.
Psychopathology, Vol. 43, No. 3, 2010, pp. 159-169.

The N terminus of monoamine transporters is a lever required for the action of amphetamines. Sucic, Sonja; Dallinger, Stefan; Zdrazil, Barbara; Weissensteiner, René; Jørgensen, Trine N; Holy, Marion; Kudlacek, Oliver; Seidel, Stefan; Cha, Joo Hwan; Gether, Ulrik; Newman, Amy H; Ecker, Gerhard F; Freissmuth, Michael; Sitte, Harald H.
Journal of Biological Chemistry, Vol. 285, No. 14, 2010, pp. 10924-38.

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Thorsen, Thor S; Madsen, Kenneth L; Rebola, Nelson; Rathje, Mette; Anggono, Victor; Bach, Anders; Moreira, Irina S; Stuhr-Hansen, Nicolai; Dyhring, Tino; Peters, Dan; Beuming, Thijs; Huganir, Richard; Weinstein, Harel; Mulle, Christophe; Strømgaard, Kristian; Rønn, Lars Christian B; Gether, Ulrik.
Proceedings of the National Academy of Science of the United States of America, Vol. 107, No. 1, 2010, pp. 413-8.

The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression. Bock, Camilla; Bukh, Jens Drachmann; Vinberg, Maj; Gether, Ulrik; Kessing, Lars Vedel.
Psychopathology, Vol. 43, No. 3, 01.01.2010, pp. 197-204.