Research – University of Copenhagen

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Neuropharmacology > Research

Molecular Neuropharmacology and Genetics Laboratory

Molecular Neuropharmacology and Genetics Laboratory counts ~35 people and is separated into five groups with focus on 1) cellular biology and genetics of neurotrans-mitter transporters/receptors (headed by Ulrik Gether), 2) molecular pharmacology and structure of neurotransmitter transporters (headed by Associate Professor Claus J. Løland), 3) cellular ‘scaffolding’ processes in the CNS (headed by Associate Professor Kenneth L. Madsen), structural biology of G protein coupled receptors and transport proteins (headed by Assistant Professor Søren G. F. Rasmussen and 5) neuronal signaling in Drosophila melanogaster (the fruit fly) (headed by Associate Professor Ole Kjærulff). All five groups are presented below.

  • Ulrik Gether Group

    The overall purpose of our research is to achieve insight into molecular, cellular and genetic processes responsible for synaptic signal transmission and how these processes can be modulated by drugs.

  • Claus Juul Løland Group

    The research focuses on structure-function relationship in neurotransmitter transporters. Specifically, how binding of ions and substrate couple to an allosteric interactions network within the transporter, leading to the translocation of the ligand into the cell.

  • Kenneth Lindegaard Madsen Group

    The research addresses fundamental aspects of basic pharmacology, molecular pharmacology and neuropharmacology.
     

  • Søren Rasmussen Group

    The research of the lab is focused on understanding the structural basis for the func-tional properties of G-protein coupled receptors (GPCRs) and neurotransmitter transporters.

  • Ole Kjærulff Group

    We study the molecular mechanisms of cell communication in the nervous system, using the fruit fly Drosophila melanogaster as our primary experimental system.

Centers of Excellence:

  • UNIK Center for Synthetic Biology

    The Center for Synthetic Biology is an crossdisciplinary research center at University of Copenhagen. Having pioneered synthetic biology as a major research focus in a European context, the Center today creates a framework for several major research initiatives that has sprung from the original UNIK Synthetic Biology initiative. Maintaining a crossdisciplinary, collaborative environment on all academic levels is a key role for the Center for Synthetic Biology.