Publications – University of Copenhagen

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Pharmacology > Publications

Molecular Pharmacology Laboratory Publications 2012

  1. Bellmann-Sickert K, Elling CE, Madsen AN, Little PB, Lundgren K, Gerlach LO, Bergmann R, Holst B, Schwartz TW, Beck-Sickinger AG. Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation. J Med Chem. 2011;54:2658-67
  2. Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Locati M, Luster A, Matsushima K, Murphy PM, Nomiyama H, Power CA, Proudfoot AEI, Rosenkilde MM, Sparre-Ulrich AH, Thelen M, Yoshie O, and Zlotnik A (alphabetic author list). IUPHAR nomenclature committee. International Union of Pharmacology Nomenclature XXIIV. Update on the Extended Family of Chemokine Receptors (NC-IUPHAR). Pharmacological Reviews, 2012 [in press]
  3. Benned-Jensen T, Mokrosinski J, and Rosenkilde MM. The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. PLoS One. 2011;6:e24644
  4. Benned-Jensen T, Norn C, Laurent S, Madsen CM, Larsen HM, Arfelt KN, Wolf RM, Frimurer TM, Sailer AW, Rosenkilde MM. Molecular Characterization of Oxysterol Binding to the Epstein-Barr Virusinduced Receptor 2 (GPR183). J Biol Chem. 2012;287:35470-83
  5. Benned-Jensen T, Smethurst C, Page KR, Sivertsen B, Blanchard AD, Jepras R, Rosenkilde MM. Ligand modulation of EBI2 – Identification of a potent and efficacious inverse agonist. J Biol Chem. 2011;286:29292-302
  6. Clemmensen C, Madsen AN, Smajilovic S, Holst B, Bräuner-Osborne H. L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances. Amino Acids. 2011;43:1265-75
  7. Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, Sakata I, Pedersen J, Windeløv JA, Füchtbauer EM, Olsen J, Sundler F, Christensen JP, Wierup N, Ol-sen JV, Holst JJ, Zigman JM, Poulsen SS, Schwartz TW. A Major Lineage of Enteroen-docrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin. Endocrinology, 2012,153: 5782-95
  8. Egerod KL, Jin C, Petersen PS, Wierup N, Sundler F, Holst B, Schwartz TW. _-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia. Int J Endocrinol. 2011;2011:401258
  9. Els S, Schild E, Petersen PS, Kilian TM, Mokrosinski J, Frimurer TM, Chollet C, Schwartz TW, Holst B, Beck-Sickinger AG. An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J Med Chem. 2012;55:7437-49
  10. Farrell HE, Abraham AM, Cardin RD, Sparre-Ulrich AH, Rosenkilde MM, Spiess K, Jensen TH, Kledal TN, Davis-Poynter N. Partial Functional Complementation Between Human and Mouse Cytomegalovirus Chemokine Receptor Homologues. Virology. 2011;85:6091-5
  11. Hansen HS, Rosenkilde MM, Holst JJ, Schwartz TW. Endogenous agonist for GPR119 as a fat sensor. Pharmacol Sci Rev. 2012;33:374-81
  12. Hansen HS, Rosenkilde MM, Holst JJ, Schwartz TW. GPR119 as a fat sensor. Trends Pharmacol Sci., 2012, 33:374-81.
  13. Hansen JB, Tonnesen MF, Madsen AN, Hagedorn PH, Friberg J, Grunnet LG, Heller RS, Nielsen AØ, Størling J, Baeyens L, Anker-Kitai L, Qvortrup K, Bouwens L, Efrat S, Aalund M, Andrews NC, Billestrup N, Karlsen AE, Holst B, Pociot F, Mandrup-Poulsen T. Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic _cell fate in response to cytokines. Cell Metab. 2012;16:449-61
  14. Hansen KB, Rosenkilde MM, Knop FK, Wellner N, Diep TA, Rehfeldt JF, Andersen UB, Holst JJ, Hansen HS. 2-Oleoylglycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metabol. 2011;96:E1409-17
  15. Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Acylation Type Determines Ghrelin’s Effects on Energy Homeostasis in Rodents. Endocrinology. 2012;153:4687-95
  16. Jensen AM, Sparre-Ulrick AH, Davis-Poynter N, Rosenkilde MM. Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure? Adv Virol. 2012;231813 (15 pages)
  17. Jensen PC, Thiele S, Elder A, Kolbeck R, Gosh S, Frimurer TM, Rosenkilde MM. Reversed binding of a small molecule ligand in homologous chemokine receptors – differential role of extracellular loop 2. Br J Pharmacol. 2012;166:258-75
  18. Kissow H, Hartmann B, Holst JJ, Hare KJ, Hansen LS, Rosenkilde MM, Poulsen SS. Glucagon-like peptide-1 (GLP-1) receptor agonists or DPP-4 inhibition do not accelerate neoplasia in carcinogen treated mice. Reg Pept. 2012;179:91-100
  19. Mokrosi_ski J, Frimurer TM, Sivertsen B, Schwartz TW, Holst B. Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop. J Biol Chem. 2012;287:33488-502
  20. Mungalpara J, Thiele S, Eriksen Ø, Eksteen J, Rosenkilde MM, Våbenø J. Rational Design of conformationally Constrained Cyclopentapeptide CXCR4 Antagonists. J Med Chem. 2012;55:10287-91
  21. Møller CL, Raun K, Jacobsen ML, Pedersen TA, Holst B, Conde-Frieboes KW, Wulff BS. Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved. Mol Cell Endocrinol. 2011;341: 9-17
  22. Nørregaard K, Benned-Jensen T, Rosenkilde MM. EBI2, GPR17 and GPR18 – structural and functional similarities. Curr Top Med Chem Rev. 2011;11:618-28
  23. Pedersen SL, Bhatia VK, Jurt S, Paulsson JF, Pedersen MH, Jorgensen R, Holst B, Stamou D, Vrang N, Zerbe O, Jensen KJ. Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36. J Pept Sci. 2012;18:579-87
  24. Petersen PS, Jin C, Madsen AN, Rasmussen M, Kuhre R, Egerod KL, Nielsen LB, Schwartz TW, Holst B. Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. FASEB J. 2011;25:3803-14
  25. Rummel PC, Arfelt KN, Baumann L, Jenkins T, Thiele S, Luttichau HR, Johnsen A, Pease J, Ghosh S, Elder A, Kolbeck R, Rosenkilde MM. Molecular requirements for CCR8 receptor inhibition – Probedependent allosteric interactions. Br J Pharmacol. 2012;167:1206-17
  26. Sivertsen B, Lang M, Frimurer TM, Holliday ND, Bach A, Els S, Engelstoft MS, Petersen PS, Schwartz TW, Beck-Sickinger AG, Holst B. Unique interaction pattern of a functionally biased ghrelin receptor agonist. J Biol Chem. 2011;286:20845-60
  27. Steen A, Rosenkilde MM. Molecular Pharmacology of CXCR4 Inhibition. Invited Review. Book chapter. Novel Developments in Stem Cell Mobilization. Editors: Fruehauf S and Calandra G. Chapter 2:23-35 (2012)
  28. Thiele S, Malmgaard-Clausen M, Engel-Andreasen, J, Steen A, Rummel PC, Nielsen M, Gloriam D, Frimurer T, Ulven T, Rosenkilde MM. Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors. J Med Chem. 2012;55:8164_77
  29. Thiele S, Steen A, Jensen PC, Mokrosinski J, Frimurer TN, Rosenkilde MM. Allosteric and orthosteric sites in the CC-chemokine receptor CCR5 – a chimeric receptor approach. J Biol Chem. 2011;286:37543-54
  30. Torekov SS, Ma L, Grarup N, Hartmann B, Hainerová IA, Kielgast U, Kissow H, Rosenkilde MM, Lebl J, Witte DR, Jørgensen T, Sandbaek A, Lauritzen T, Madsen OD, Wang J, Linneberg A, Madsbad S, Holst JJ, Hansen T, Pedersen OB. Homozygous carriers of the G-allele of rs4664447 of the glucagon gene (GCG) are characterized by decreased fasting and stimulated levels of insulin, glucagon and GLP-1GLP2, GCG. Diabetologia. 2011;54:2820-31
  31. Ugleholdt R, Pedersen J, Füchtbauer -M, Kissow HL, Nytofte N, Poulsen SS, Rosenkilde MM, Seino Y, Thams PG, Holst PJ, Holst JJ. Adipocyte Glucose-dependent Insulinotropic Polypeptide receptor restores high fat diet induced body weight gain in mice. J Biol Chem. 2011;286:44632-45
  32. Valentin Hansen L, Holst B, Frimurer TM, Schwartz TW. PheVI:09 (Phe6.44) as a sliding micro-switch in 7TM G protein coupled recepAnnual Report 2012 35 tor activation. J Biol Chem. 2012;287:43516-26
  33. Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch DG, Ueda N, Hansen H. Studies on the anorectic effect of N_acylphosphatidylethanolamine and phosphatidylethanolamine in mice. Biochim Biophys Acta. 2011;1811:508-12